According to Dr. Calvin Hirsch, a dvancement in glycation research is gaining momentum in the past several years. Researchers have been able to demonstrate that advanced glycation affects neutrophil viability, migration, and clustering. They have shown that high-molecular-weight hyaluronic acid inhibits the activation of NF-kappaB and suppresses the expression of cytokines. But, the exact mechanisms of advanced glycation are not yet understood.
The development of AGEs is accelerated by the overcooking of animal products, as well as by excessively high-heat cooking of food. High-heat cooking results in scorched sugars and fats that speed up the process. These foods include prepackaged foods, homogenized products, and canned and frozen meals. However, there are dietary interventions that can reduce the intake of AGEs. In particular, low-heat cooking methods have been shown to produce more moisture in the food, which reduces the accumulation of AGEs.
Mice with the AGEs injected into their brains exhibit symptoms of dementia and other aging conditions. A water maze experiment was conducted in three groups of mice. The amount of time spent in the target area was measured, as was the number of times the mice crossed the platform. Researchers also measured the residence time of mice in the new arm of a Y-maze. As a result, it appears that the mice are more likely to develop dementia.
Dr. Calvin Hirsch described that, while diabetes and aging populations are significant burdens on the health care system, glycation and AGEs are a potential link between the two. In fact, recent research suggests that receptors for AGEs may be involved in the development of both conditions. Mice injected with AGEs developed significant characteristics of AD, including decreased memory and elevated levels of phosphorylated tau and APP. In humans, the role of AGEs in aging is unclear.
AGEs interfere with normal functions of proteins. These molecules disrupt molecular conformation, reduce enzymatic activity, and inhibit receptor-mediated signal pathways. Advanced glycation causes cellular damage and organopathy. It disrupts receptor-mediated signal pathways and oxidative stress. In cardiovascular disease, glycation impairs arterial and myocardial compliance and increases vascular stiffness. Further, glycation inhibits the production of type III collagen and a3(IV) collagen.
AGEs affect the metabolism of glucose in skeletal muscle and adipocyte cells. AGE-derived albumin is known to induce the formation of intracellular reactive oxygen species, which inhibit glucose uptake. The glycated form of adipocyte cells contributes to the oxidative modification of intracellular proteins. This is why glycated albumin is highly reactive in aging. Therefore, there are many ways to measure glycation and AGE-induced cell damage.
High levels of AGEs can affect the reproductive system. Acute glycation can affect the viability of nerve cells. In the reproductive system, high AGE levels can increase the risk of infertility. Consuming more refined carbohydrates increases blood sugar levels and the rate of glycation in the body. It is also linked to the development of a variety of diseases, including diabetes. Inflammatory responses to high glucose levels are one of the main factors leading to infertility.
In addition to Dr. Calvin Hirsch studies have shown that a specific treatment, aminoguanidine, reverses abnormal wound healing in diabetic patients. Researchers are now studying how these compounds affect the immune system. The treatment of advanced glycation may include a natural compound that reverses the effects of aging in diabetic patients. So, if you are looking for a way to reduce the effects of aging on wound healing, check out the latest research on this topic!
High levels of AGEs have been linked to a number of age-related diseases. People with high blood sugar also tend to have higher levels of AGEs in their blood, which contributes to the decline of several organs. And if you're a diabetic, you may want to look into the benefits of a low-AGE diet. It can also help delay the onset of cataract. In some people, it is possible to avoid diabetes by eating less processed food.